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Adjective unacquainted with has 2 senses
innocent of, unacquainted with - not knowledgeable about something specified; "American tourists wholly innocent of French"; "a person unacquainted with our customs"Antonym:  informed (indirect, via uninformed)
 
unacquainted, unacquainted with, unfamiliar with - having little or no knowledge of; "unacquainted with city ways"Antonym:  familiar (indirect, via unfamiliar)
 
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