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Definitions from WordNet

Definitions from the Web

Kinase

A kinase is a type of enzyme that catalyzes the transfer of phosphate groups from high-energy donor molecules, such as ATP, to specific target molecules. These target molecules are often proteins, and the addition or removal of phosphate groups can alter their activity and function.

Senses:

1. Protein kinase: A type of kinase that specifically phosphorylates proteins, regulating various cellular processes. Protein kinases are crucial for signal transduction, cell division, and other important biological functions. Common examples include protein kinase A (PKA) and protein kinase C (PKC).

2. Tyrosine kinase: A subtype of protein kinase that specifically phosphorylates tyrosine residues in proteins. Tyrosine kinases play key roles in cell growth, signal transduction, and the development of certain diseases, including cancer. Examples include epidermal growth factor receptor (EGFR) and BCR-ABL tyrosine kinase.

3. Serine/threonine kinase: A subtype of protein kinase that phosphorylates serine and threonine residues in proteins. Serine/threonine kinases are involved in important cellular processes such as cell cycle regulation, apoptosis, and cellular signaling. Examples include cyclin-dependent kinase (CDK) and protein kinase B (Akt).

Sample Sentences:

• The activation of protein kinases is critical for transmitting signals within cells.
• Mutations in tyrosine kinases can result in abnormal cell growth and the development of cancer.
• Inhibiting certain serine/threonine kinases has shown potential for treating neurodegenerative diseases.
• Phosphorylation by kinases regulates the activity of many proteins in the human body.

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