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Adjective irritable has 3 senses
cranky, fractious, irritable, nettlesome, peevish, peckish, pettish, petulant, testy, tetchy, techy - easily irritated or annoyed; "an incorrigibly fractious young man"; "not the least nettlesome of his countrymen"Antonym:  good-natured (indirect, via ill-natured)
 
irritable - abnormally sensitive to a stimulusAntonym:  insensitive (indirect, via sensitive)
 
excitable, irritable - capable of responding to stimuliAntonym:  insensitive (indirect, via sensitive)
 
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